Abstract

Objective To analyze the correlation of abnormal karyotypes with recurrent spontaneous abortion. Methods The chromosomal karyotypes were examined in 279 couples with spontaneous abortion history by using peripheral blood lymphocyte culture and G banding. Results 151 cases of 279 couples were abnormal in karyotype, with an abnormal rate of 27.1%. Among them, there were 12% chromosome structural aberrations (18/151) including 11 translocations, five inversions, one insertion and one deletion and 88.1% chromosome polymorphism (133/151) consisting of 108 Y chromosome and 25 other chromosome variations. Conclusion Y chromosome polymorphism is a significant genetic factor resulting in recurrent spontaneous abortion. Additionally, the balanced translocation, inversion and polymorphism also have correlations with spontaneous abortion. Their correlations should be further studied to provide reliable data for genetic counseling and eugenics. Key words: Recurrent spontaneous abortion; Chromosome; Abnormal karyotype

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