Abstract
Background: Marginal zone lymphomas are indolent B-cell lymphomas associated with autoimmunity and chronic inflammation. The two most frequent variants are mucosa associated lymphoid tissues marginal zone lymphomas and splenic marginal zone lymphomas. The aim of the study was to determine if it is possible to classify splenic and gastric lymphomas according to karyometric features.Methods: The material consisted of 16 splenic and 14 gastric lymphomas. The measurements were done with the AnalySIS image analysis system. In each case at least 100 nuclei were selected, and 19 different geometric parameters were measured.Results: On statistical analysis, the nuclei of splenic and gastric lymphomas showed differences in most parameters, but significant overlap of the values was present. Neural networks were trained and used for classification of the data. By this method, the nuclei were properly classified with a sensitivity of 0.75 and specificity of 0.71. In addition, in all the cases the majority of the nuclei were properly classified, thus allowing correct classification of all the cases into “splenic” or “gastric”.Conclusion: These results support the view that mucosa-associated lymphoid tissue lymphomas and splenic marginal-zone lymphomas are separate entities.
Highlights
Marginal zone lymphomas are indolent B-cell peripheral lymphomas that comprise three distinct clinicopathological entities: extranodal marginal zone lymphomas of mucosa-associated lymphoid tissues, splenic marginal zone lymphomas and nodal marginal zone lymphomas
These results support the view that mucosa-associated lymphoid tissue lymphomas and splenic marginal-zone lymphomas are separate entities
The aim of the study was to find quantitative differences between the two most frequent types of marginal zone lymphomas, gastric MALT type and primary splenic lymphomas, and to test the feasibility of an automatic classification based on karyometric features
Summary
Marginal zone lymphomas are indolent B-cell peripheral lymphomas that comprise three distinct clinicopathological entities: extranodal marginal zone lymphomas of mucosa-associated lymphoid tissues, splenic marginal zone lymphomas and nodal marginal zone lymphomas. In the current classification of the World Health Organization these are considered separate entities. A significant relationship was shown between a chronic inflammatory process and autoimmunity. In total these lymphomas constitute about 6% of nonHodgkin lymphomas [1,2,3,4]. Marginal zone lymphomas are indolent B-cell lymphomas associated with autoimmunity and chronic inflammation. The aim of the study was to determine if it is possible to classify splenic and gastric lymphomas according to karyometric features
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