Abstract
A 60-year-old male with a history of type 2 diabetes and hypertension, exhibited a 1.93 g/dL monoclonal protein band by serum protein electrophoresis (SPE; Hydrasys, Sebia). Subsequent immunofixation electrophoresis (IFE, Sebia) showed that the band consisted of monoclonal IgG-kappa antibodies. A bone marrow biopsy was performed and revealed the presence of 30 to 40% plasma cells. CD138 staining revealed numerous large clusters of stain in the focal areas of greater than 90% of cells. The patient was treated with thalidomide and dexamethasone which demonstrated partial remission. For the next few years, his condition was stable. He returned to the hematology–oncology clinic on a monthly or bi-monthly basis for follow-up SPE and free light chain analysis. Figure 1, A to C (January to June 2017) shows representative SPE densitometric scans during this time of partial remission, showing a very faint band in the gamma globulin region (see arrows). Free kappa...
Published Version
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