Kaposi's Sarcoma: Pathophysiology and Clinical Management

Abstract

Kaposi's sarcoma, a rare tumor previously known mostly to dermatologists, pathologists, and oncologists, has become almost commonplace since the onset of the acquired immunodeficiency syndrome (AIDS) in the early 1980s. Its sudden leap to prominence has increased interest in understanding the tumor. Unfortunately, the pathogenesis of Kaposi's sarcoma remains unknown despite a plethora of theories. Similarly, because of the short life-span of patients with AIDS, definitive information regarding the treatment of AIDS-related Kaposi's sarcoma is unavailable. Despite these difficulties, Drs Ziegler and Dorfman have edited a text that provides comprehensive, current information on Kaposi's sarcoma including the theories of origin and pathophysiology as well as the clinical features and management of the disease. Both editors have had extensive experience with Kaposi's sarcoma prior to the AIDS epidemic. The majority of the 12 other contributors are also from the San Francisco area and have extensive experience dealing with AIDS-related Kaposi's sarcoma.