Abstract
Background Infection with human herpesvirus 8 (HHV-8), also known as Kaposi sarcoma associated herpesvirus, is associated with the development of primary effusion lymphoma and Kaposi sarcoma. A transmembrane protein of HHV-8, K1, is readily expressed in these tumors, and the expression of K1 alone causes hyperplasia of lymph nodes and lymphomas in mice. The exact mechanism of how K1 causes hyperplasia and lymphomas in K1-expressing mice is not known. The cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM) of K1 was previously shown to be involved in activation of nuclear factor-kappa B (NF-κB). Moreover, we have recently shown that K1 suppresses Fasmediated apoptosis through its extracellular immunoglobulin-like domain and that K1-transfected mice survive a lethal dose of agonistic anti-Fas antibody (Jo2). We thus hypothesized that development of hyperplasia and lymphomas in K1-expressing mice is driven by alterations in Fas signaling.
Highlights
Infection with human herpesvirus 8 (HHV-8), known as Kaposi sarcoma associated herpesvirus, is associated with the development of primary effusion lymphoma and Kaposi sarcoma
We hypothesized that development of hyperplasia and lymphomas in K1-expressing mice is driven by alterations in Fas signaling
Gross examination of thoracic and abdominal cavities of transgenic mice with K1 expression driven by a ubiquitous promoter, which were sacrificed at 18 months of age, revealed enlarged cervical, mediastinal, renal, and mesenteric lymph nodes and spleens
Summary
Address: Department of Lymphoma and Myeloma, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA * Corresponding author from 11th International Conference on Malignancies in AIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research Bethesda, MD, USA. Published: 17 June 2009 Infectious Agents and Cancer 2009, 4(Suppl 2):P37 doi:10.1186/1750-9378-4-S2-P37. phlettmpe:/n/wt>wmeePnrtorcale.ceodmin/gcsoonftethnet/p1d1ft/h17In5t0e-r9n3a7ti8o-n4a-Sl 2C-oinnfofe.prednf MAIDS and Other Acquired Immunodeficiencies (ICMAOI): Basic, Epidemiologic, and Clinical Research Publication of this supplement was made possible with support from the Office of HIV and AIDS Malignancy, National Cancer Institute, National Institutes of Health. Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here.
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