Kaposi's Sarcoma Associated With Multiple Myeloma

Abstract

Since Moricz Kaposi's original description1of idiopathic multiple pigment sarcoma of the skin, nearly 1,000 publications have appeared documenting an estimated 1,200 patient summaries.2,3Reviews of this subject4-8have established the frequent association with other neoplasms, among which lymphoreticular are the most common, especially Hodgkin's disease, lymphosarcoma, and lymphatic leukemia. In contrast, the reported association with multiple myeloma has been rare.7,8 The purposes of this paper are as follows: (1) to describe a patient with multiple myeloma who developed classic lesions of Kaposi's sarcoma during treatment with an alkylating agent; (2) to suggest the possibility of a greater association of multiple myeloma with Kaposi's sarcoma than heretofore noted; and (3) to suggest the possible occurrence of serum protein abnormalities which may be due to Kaposi's sarcoma per se. Patient Summary A 63-year-old white male truck driver was in excellent health until June 1965, when he developed