Abstract
7岁患儿以左眼结膜出血、凝血因子减少及血小板减少为首发表现，影像检查发现颅面、肺间质和脾脏受侵犯，因不能手术未获标本进行病理检查。丙种球蛋白、糖皮质激素等治疗无效，西罗莫司初始治疗有部分效果但后续又加重，改用曲美替尼治疗后病情缓解。外周血循环肿瘤细胞DNA检测发现NRAS 基因c.182A>G（p.Q61R）突变，确诊为卡波西样淋巴管瘤病。口服曲美替尼治疗11个月，左眼结膜出血未再反复，脾脏缩小，肺间质病变逐渐好转。.
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Schedule a callMore From: Zhonghua er ke za zhi = Chinese journal of pediatrics
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