Abstract
Kaposi sarcoma (KS) occurs in 4 distinct settings categorized as classic KS, African-endemic KS, epidemic (acquired immunodeficiency syndrome [AIDS]—related) KS, and iatrogenic (immunosuppressive drug—associated) KS. 1 A new human herpesvirus, designated KS—associated herpesvirus (KSHV) or human herpesvirus type 8 (HHV-8), was first identified by Chang et al 2 in tissue from patients with epidemic KS. Subsequent studies demonstrated KSHV in tissue from patients with the other 3 forms of KS. 3,4 However, the reported cases of iatrogenic KS have all been in patients receiving organ transplants. Recently, KSHV has also been found in AIDS—related body cavity—based lymphomas, Castleman disease, and various cutaneous squamoproliferative lesions in patients receiving organ transplants. 5-7 Interestingly, some cases of AIDS-related body cavity—based lymphomas were also shown to contain Epstein-Barr virus (EBV) DNA sequences. To our knowledge, the association of KSHV and EBV has not been reported previously in lesional KS tissue. We describe an
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