Abstract
This study investigated the effects of ribavirin, proanthocyanidin, and ribavirin-proanthocyanidin in dogs naturally infected with canine distemper virus (CDV). Five groups were created, each with six dogs aged 2-6 months: one healthy control group and four patient groups. For ten days, the A group received classical treatment (CT) [fluid treatment and antibiotic], the A+R group received CT + ribavirin, the A+P group received CT + proanthocyanidin, A+R+P group received CT + ribavirin-proanthocyanidin. On days T0, T3, T7, and T10, hematological, biochemical, and clinical scores were done. These days and the fifth and tenth post-treatment days were also screened for CDV. Clinical improvement was best in the A+P, A+R, A, and A+R+P groups, respectively. The A+R group had fewer leucocytes, neutrophils, and monocytes (P
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