Abstract
Objective: This study was to investigate the effect of the Chinese herbal compound Kanggan granule (KG) on immune function in a mouse model of immunosuppression and its possible mechanism of action. Method: ICR mice were randomly divided into a normal control group (untreated non-immunosuppressed, Control), untreated immunosuppressed group (Model), positive control group (immunosuppressed and treated with 1.6 g/kg astragalus granule [AG]), high-dose KG group (immunosuppressed and treated with 24 g/kg, KG-24), and low-dose KG group (immunosuppressed and treated with 6 g/kg, KG-6). Each group received intragastric administration once daily for 7 days. Immunosuppression was induced by an intraperitoneal injection of dexamethasone (25 mg/kg) once daily beginning on day 1 for 3 days. To illuminate the mechanism of immunomodulatory, we studied the effects of KG on nonspecific immunity, humoral immunity and cellular immunity in mice respectively. Results: KG improved organ weights and improved the phagocytic ability of mononuclear macrophages in immunosuppressed mice (p p p +/CD8+ ratio in immunosuppressed mice (p p Conclusions: KG can improve immune function in immunosuppressed mice. Nonspecific immunity, humoral immunity, and cellular immunity were all enhanced.
Highlights
The immune system is indispensable for our body
To illuminate the mechanism of immunomodulatory, we studied the effects of Kanggan granule (KG) on nonspecific immunity, humoral immunity and cellular immunity in mice respectively
KG consists of Jinyinhua (Lonicerae japonicae Flos, the dry flower bud or early blossoms of Lonicera japonica Thunb, Caprifoliaceae), Mianmaguanzhong (Dryopteridis Crassirhizomatis Rhizoma, the rhizome of Dryopteris crassirhizoma Naki, Dryopteridaceae), and Chishao (Paeoniae Radix Rubra, the root of Paeonia lactiflora Pall or Paeonia veitchii Lynch, Ranunculaceae)
Summary
The immune system is indispensable for our body. Researchers have found that the immune system plays an important role in both the induction and treatment of disease, including cancer, acquired immunodeficiency syndrome, and inflammation [2] [3] [4]. Studying drugs that act on the immune system is necessary so that immune system-related diseases can be more effectively treated. Dryopteridis Crassirhizomatis Rhizoma has been reported to be useful for the treatment of influenza virus [8]. Previous studies showed that Paeoniae Radix Rubra protects the liver and has antioxidant activity [9] [10]. The effects of KG on some immune system-related diseases have been reported in clinical studies [11] [12], little preclinical experimental information about KG is available. We investigated the effects of KG on immune function in immunosuppressed mice and evaluated the mechanism of action of KG to provide a basis for adding the new indication of KG in the immune system
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