Kalsiyum kanal blokerlerinin laringoskopi ve trakeal entubasyona bağlı kardiyovasküler değişikliklere etkilerinin karşılaştırılması

Abstract

OBJECTIVES: In this study, the effects of verapamil and diltiazem (calcium channel blockers) were compared in preventing reflex cardiovascular effects caused by laryngoscopy and tracheal intubation. METHODS: Sixty patients were randomly divided into three groups: 1. group 0.1 mg / kg verapamil, second group 0.3 mg / kg diltiazem, third group 2 cc saline intravenous bolus. In terms of haemodynamic follow-up, changes in MAP, RPP and HR were evaluated according to time. RESULTS: Significant increases were observed in all three groups of patients in the HR until 4 minutes after intubation. No significant difference was observed between the 3 groups in terms of heart rhythm. Significant increases in MAP and RPP values after intubation were significantly inhibited in the verapamil and diltiazem groups. There was no significant difference between verapamil and diltiazem groups about MAP and RPP values. CONCLUSION: Verapamil and diltiazem did not significantly affect HR. Preventing the increase of the mean arterial pressure and RPP were found to be effective in both drugs, but there was no significant difference between the drugs. Therefore, it is concluded that both drugs may be used to prevent hypertensive episodes, especially in patients with ischemic hypertensive patients, patients with Increased intracranial pressure disease, and other conditions in which hemodynamic effects are not desired in response to intubation.