Kalihiacyloxyamides A-H, α-acyloxy amide substituted kalihinane diterpenes isolated from the sponge Acanthella cavernosa collected in the South China Sea

Abstract

Eight unreported α-acyloxy amide substituted kalihinane diterpenes, named kalihiacyloxyamides A-H were isolated from the South China Sea sponge Acanthella cavernosa. The planar structures and absolute configurations were elucidated by detailed 1D and 2D NMR experiments along with HRESIMS analysis, single crystal X-ray diffraction and CD spectroscopic analysis. Two compounds showed significant cytotoxicity against K562 cell line with IC50 values of 6.4 and 6.3 μM, while two other compounds displayed moderate cytotoxicity against MDA-MB-231 with IC50 values of 7.3 and 7.9 μM.