Kajian Pustaka: Pemanfaatan Tikus Sebagai Hewan Model Trauma Tumpul (Kontusio)

Abstract

The occurrence of contusion in humans and animals becomes an interesting study material, many researchers search and do a treatment formulation for contusion. The various effects of applying a new substance/drug to humans can be determined by studying cumulative effect of doses at the preclinical stage. The information was obtained from conducting laboratory experiments in vivo using experimental animals as a model designed in preclinical tests, such as using rats (Rattus norvegicus). So far, the development of using rat as an animal model of contusion is still very potential for further study. This literature review discusses about the use of animals as contusion models, rat trends as contusion animal models, ethical principles and animal welfare animal models, explanation and classification of contusion, contusion methods, and aspects of future animal development models as research subjects.