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Abstract
The effects of striatal kainic acid lesions on [ 3H]cis-flupenthixol ([ 3H]FPT) and [ 3H]spiperone ( 3H-SPIP) binding to dopamine (DA) receptors in control and lesioned striata were examined. Significant reductions in both binding parameters were observed, [ 3H]FPT binding was depleted to a greater extent than [ 3H]SPIP binding. Reductions in both [ 3H]FPT and [ 3H]SPIP binding were significantly correlated with reductions in glutamic acid decarboxylase activity. After complete loss of GAD activity, 30–40% of [ 3H]SPIP binding sites remained in the lesioned striata, whereas all [ 3H]FPT binding sites were destroyed. The results are discussed in relation to the presence of distinct types of DA receptors in rat striatum, and ligand binding to these receptors.
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