Abstract
The current study explored the expression of KAI1/CD82 and MRP1/CD9 and its significance in laryngeal squamous cell carcinoma (LSCC). The expression levels of KAI1/CD82 and MRP1/CD9 in 100 LSCC tissue specimens, as well as in 30 para-LSCC non-carcinomatous tissue specimens randomly taken from the patients, were assessed using the quantitative polymerase chain reaction (Q-PCR) and immunohistochemistry and correlations with pathological parameters of LSCC and their influence on survival function were analyzed. KAI1/CD82 and MRP1/CD9 showed basically consistent changes in both mRNA and protein expression. Their expression in the 30 LSCC specimens was significantly lower compared with that in the corresponding non-carcinous tissues (P < 0.01 or 0.05), notably correlating with TNM stage, differentiation degree, clinical stage, and lymphatic metastasis (P < 0.01 or 0.05), but not gender, age, and LSCC growth sites (P > 0.05). The median survival of patients with positive KAI1/CD82 and MRP1/CD9 protein expression was longer than that of patients with negative protein expression (P < 0.01 or 0.05). KAI1/CD82 protein expression negatively correlated with MRP1/CD9 protein expression in LSCC (χ(2) = 31.25, P < 0.01). KAI1/CD82 and MRP1/CD9 may jointly participate in the development of LSCC. They may serve as the markers for judging the infiltration, metastasis, and prognosis of LSCC.
Highlights
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies occurring in the head and neck area
The current study explored the expression of KAI1/CD82 and MRP1/CD9 and its significance in laryngeal squamous cell carcinoma (LSCC)
The expression levels of KAI1/CD82 and MRP1/CD9 in 100 LSCC tissue specimens, as well as in 30 para-LSCC non-carcinomatous tissue specimens randomly taken from the patients, were assessed using the quantitative polymerase chain reaction (Q-PCR) and immunohistochemistry and correlations with pathological parameters of LSCC and their influence on survival function were analyzed
Summary
Laryngeal squamous cell carcinoma (LSCC) is one of the most common malignancies occurring in the head and neck area. The incidence of LSCC is on the increase, and its infiltration and metastasis have become the primary factors greatly influencing patients’ quality of life and causing deaths. Ideal markers of LSCC for prognostic judgment and therapeutic guidance remain urgent in clinical practice. The transmembrane 4 superfamily (TM4SF) embraces CD37, CD53, ME491/CD63, TAPA1/CD81, KAI1/CD82, and MRP1/CD9, and is correlated with the movement, proliferation, and metastasis of tumor cells (Woegerbauer et al, 2010; Chen et al, 2011). KAI1/CD82 and MRP1/CD9 have been extensively studied.
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