Abstract
BackgroundKaempferol has been proposed as a potential drug for cancer chemoprevention and treatment because it is a natural polyphenol contained in plant-based foods. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on this finding, we investigated the mechanisms by which kaempferol produces the anti-metastatic effect in human tongue squamous cell carcinoma SCC4 cells.Methodology/Principal FindingsIn this study, we provided molecular evidence associated with the anti-metastatic effect of kaempferol by demonstrating a substantial suppression of SCC4 cell migration and invasion. This effect was associated with reduced expressions of MMP-2 and TIMP-2 mRNA and protein levels. Analysis of the transcriptional regulation indicated that kaempferol inhibited MMP-2 transcription by suppressing c-Jun activity. Kaempferol also produced an inhibitory effect on the phosphorylation of ERK1/2.ConclusionsThese findings provide new insights into the molecular mechanisms involved in the anti-metastatic effect of kaempferol, and are valuable in the prevention of oral cancer metastasis.
Highlights
Oral squamous cell carcinomas (OSCC) are the sixth most common malignancy worldwide and the fourth leading cause of cancer deaths among men in Taiwan [1]
These findings provide new insights into the molecular mechanisms involved in the anti-metastatic effect of kaempferol, and are valuable in the prevention of oral cancer metastasis
We demonstrate that the suppression of metastatic ability by kaempferol is produced by the down-regulation of Matrix metalloproteinases (MMPs)-2 expression, and we hope to provide a foundation for further research
Summary
Oral squamous cell carcinomas (OSCC) are the sixth most common malignancy worldwide and the fourth leading cause of cancer deaths among men in Taiwan [1]. Degradation of basement membranes and stromal extracellular matrix (ECM) components constitutes a crucial process during local tissue invasion and metastasis [5]. The structure and substrate of the MMPs family allows it to be divided into subgroups of collagenases, stromelysins, gelatinases, membrane-type MMPs, and other MMPs [7]. These are crucial to normal physiological processes, such as embryonic development, inflammation, angiogenesis, and wound healing. Recent studies have demonstrated that kaempferol protects against cardiovascular disease and cancer. Based on this finding, we investigated the mechanisms by which kaempferol produces the anti-metastatic effect in human tongue squamous cell carcinoma SCC4 cells
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
