Abstract
Polyene macrolide antibiotic pimaricin reacts with dialkyl(diaryl) phosphites and 4-bromobenzaldehyde to form 3′-N-α-[dialkoxy(diphenoxy)phosphinoyl]benzyl derivatives. Physicochemical and biological properties of the synthesized derivatives have been studied. According to the biological assay, the 3′-N-α-[dialkoxy(diphenoxy)phosphinoyl]benzyl derivatives are less toxic than the parent antibiotic and exhibit strong antifungal activity towards a wide range of Candida yeast-like fungi.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
