Abstract
AbstractA metal‐free formylation of imidazopyridines by direct decarboxylative cross‐coupling of glyoxylic acid in presence of K2S2O8 as oxidant under mild and neutral conditions is described. This reaction features a broad substrate scope, good functional group tolerance, and generates products in good yields between 68–85 %. The translational capacity of the reaction from a laboratory methodology to gram‐scale synthesis has also been ensured. The involvement of a radical pathway has been demonstrated by radical trapping experiments with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) and 2,6‐di‐tert‐butyl‐4‐methylphenol (BHT).
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