Abstract
AbstractAn efficient and regioselective trifluoromethylation method of indole at the C2 position with ecologically‐sound Langlois’ reagent (CF3SO2Na) under metal‐free conditions is described. K2S2O8 in presence of glucose at room temperature has been utilized for the generation of CF3 radicals from CF3SO2Na. The desired product can be obtained in good to excellent yields with a wide scope of substrate variability and gram scalability.
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