Abstract
Cell-surface K2P1 channels are most often electrically quiet despite their widespread expression in excitable tissues. Previously, we studied human K2P1 expressed in Chinese hamster ovary cells and found one small ubiquitin-like modifier protein (SUMO) conjugated to one K2P1 subunit to be sufficient to silence the dimeric channels (Plant et al., 2010, PNAS 107). Here, we assess K2P1 sumoylation in cultured rat cerebellar granule neurons (CGN). K2P channels have been posited to produce IKso (the standing outward potassium current responsive to changes in pH and volatile anesthetics) in CGN.
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