K2CO3/PG DES promoted transition metal free room temperature synthesis of nitroaldols and nitroolefins

Abstract

In this work, we have described the use of K2CO3/Propylene Glycol (PG) deep eutectic solvent (DES) as green and efficient alternative to volatile organic solvents for the formation of a very important reaction intermediate i.e., nitroaldols via Henry Reaction. Interestingly, the DES acted both as the solvent as well as the catalyst without the assistance of external base, solvent and additive. Further, the obtained nitroaldol product was utilized for nitroolefin synthesis.