Abstract
Background Diabetic kidney disease (DKD) is a common microvascular chronic complication affecting approximately 40% of patients with diabetes mellitus (DM). DKD is one of the major causes of kidney failure in many countries, and is associated with increased health system costs. Kidney transplantation is the treatment of choice for a significant portion of patients with end-stage kidney disease, including DM patients. In this context, acute rejection (AR) is a major post-transplant complication. The use of biomarkers as a method to prognosticate or detect early pathologic events in kidney transplantation is an attractive and needed strategy. Several studies have evaluated the relevance of genetic variants, including the K121Q polymorphism (rs1044498) in the ENPP1 gene, as predictors for the development of diabetes, DKD and, more recently, AR in kidney transplantation.
Highlights
Diabetic kidney disease (DKD) is a common microvascular chronic complication affecting approximately 40% of patients with diabetes mellitus (DM)
K121Q snp of ENPP1 gene is associated with acute rejection in kidney transplantation
Kidney transplantation is the treatment of choice for a significant portion of patients with end-stage kidney disease, including DM patients
Summary
Diabetic kidney disease (DKD) is a common microvascular chronic complication affecting approximately 40% of patients with diabetes mellitus (DM). K121Q snp of ENPP1 gene is associated with acute rejection in kidney transplantation Denise Alves Sortica*, Bruna Bellincanta Nicoletto, Pâmela Sachs Nique, Laura Bem Olivo, Evylyny Gomes Malaquias, Andrea Carla Bauer, Daisy Crispim, Roberto Ceratti Manfro, Luis Henrique Canani From 20th Brazilian Diabetes Society Congress Porto Alegre, Brazil.
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