Abstract
The K- ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa ( n=106), transitional mucosa ( n=69) and tumours ( n=149) from 149 patients with colorectal adenocarcinomas. K- ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, but not in the normal mucosa. Further, mutation rates were increased in younger patients ( P=0.001) and in mucinous carcinomas (50%) compared with well differentiated (17%), moderately differentiated (26%) or poorly differentiated (24%) tumours. Our findings indicate that mucinous carcinoma may represent a distinct genetic entity.
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