Abstract
This review presents the analysis of the systematized data on human juxtaoral organ (JOO) development, structure and function based on the results of classical and recent morphological studies. JOO morphogenesis is traced, including the appearance of its anlage at the bottom of the primitive mouth, epithelial invagination into the mesenchyme, JOO detachment from the oral epithelium, its innervation, connective tissue capsule formation, and final maturation. The analysis of the results of macroscopical, histological, electron microscopical, histochemical and immunohistochemical studies is presented, suggesting high metabolic and synthetic activity of its epithelium, which expresses several neural markers, and emphasizing a rich innervation of both its epithelial and stromal components. The findings supporting the concepts of JOO secretory and mechanosensory functions, are examined. The data on the differential diagnosis between JOO and tumoral processes are discussed, as well as the pathological changes of JOO itself and their significance for the diagnosis of the diseases.
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