Juxtaglomerular Cell Tumor in Pregnancy

Abstract

In Brief BACKGROUND Although rare, two thirds of juxtaglomerular cell tumors of the kidney occur in young women in their reproductive years. CASE A primigravid woman with a 6-year history of chronic hypertension was evaluated for the sudden onset of uncontrolled hypertension, proteinuria, and hypokalemia at 16 weeks' gestation. An abdominal sonogram revealed a left flank mass, and magnetic resonance imaging confirmed that the mass was of renal origin. The worsening hypertension was not controlled with labetolol, methyldopa, nifedipine, or hydralazine, and required a nitroglycerine drip. The patient had left nephrectomy and subsequently miscarried at 19 weeks' gestation. Her blood pressure gradually decreased and normalized within 6 months. A pathologic examination of the renal mass confirmed that it was a juxtaglomerular cell tumor. CONCLUSION This tumor should be considered in the differential diagnosis as a cause of severe hypertension in pregnancy. Juxtaglomerular cell tumors are a rare cause of malignant hypertension during pregnancy.