Abstract
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. Juvenile-onset SLE (jSLE)?also called childhood-onset SLE?is usually defined as SLE with disease-onset before the 18th birthday. Patients with jSLE are reported to account for up to 20% of all SLE patients. The estimated incidence of jSLE is between 0.36 and 2.5 per 100,000 children, which is much lower than that of adultonset SLE: 1 to 25 per 100,000.
Highlights
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems
The ACR-1997 shows 89.6% sensitivity and 98.1% specificity in adult-onset SLE, compared to 84.3% sensitivity and 94.1% specificity in Juvenile-onset SLE (jSLE). This reduced sensitivity is because the symptoms that develop in jSLE at the onset are usually partially those that develop in adult-onset SLE patients
We must wait for verification of the utility of the ACR/European League Against Rheumatism (EULAR) 2019 criteria [10], these figures indicate that precise diagnosis in jSLE patients is difficult
Summary
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects multiple organ systems. JSLE and adult-onset SLE patients differ in terms of clinical symptoms. Some reports describe the disease severity of jSLE patients compared to adult-onset SLE patients [1114].
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