Juvenile idiopathic arthritis in Jordan: single center experience

Raed M Alzyoud,Bushra N Aladaileh,Mohammad K Alnoubani,Heba Q Almaaitah,Motasem O Alsuweiti,Adel M Alwahadneh

doi:10.1186/s12969-021-00572-8

Raed M Alzyoud, Bushra N Aladaileh + Show 4 more

Open Access

https://doi.org/10.1186/s12969-021-00572-8

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Abstract

BackgroundJuvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders, including all forms of arthritis, which develops in children who are less than 16 years old. This study aimed to evaluate the clinical and laboratory features of JIA in a single center in Jordan.MethodsA retrospective analysis of the electronic medical records of Pediatric patients diagnosed with JIA based on the International League of Associations for Rheumatology (ILAR) criteria during the period from 2015 to 2019 at the Pediatric Rheumatology Clinic in the Queen Rania Children’s Hospital. All patients were below the age of 14 years at the time of diagnosis and followed for at least 6 months. Collected data consisted of age, gender, age at initial presentation and diagnosis, JIA subtype, laboratory data, treatment options, and outcome.ResultsA total of 210 patients were included in this cohort (94 males and 116 females) with the mean age at diagnosis and mean age at onset of 5.33 ± 3.40 years and 5.08 ± 3.40 years (range: 7 months – 14 years), respectively. Oligoarticular JIA was the commonest subtype (54.7%), followed by systemic arthritis (17.1%) and polyarticular arthritis (12.3%). ANA was positive in 70 patients (33.6%). Uveitis occurred in 30 (14.2%) patients.ConclusionTo the best of our knowledge, this study on this cohort is the first report on JIA in Jordan, in comparison with other regionally and internationally published reports. Oligoarticular JIA was found to be the most common subtype. For detailed knowledge on JIA characteristics and patterns, a population-based, rather than a single center study, should be conducted in Jordan.

Highlights

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders, including all forms of arthritis, which develops in children who are less than 16 years old
Juvenile idiopathic arthritis (JIA) is an inflammatory disorder characterised by chronic arthritis and comprising all forms of arthritis that develop in children younger than 16 years of age
Juvenile idiopathic arthritis has been classified by the International League of Associations for Rheumatology (ILAR) into the following seven subtypes: systemic, oligoarticular, rheumatoid factor (RF) positive and RF negative polyarticular, enthesitis-related arthritis (ERA), psoriatic, and ‘other’ JIA [3]

Summary

Introduction

Juvenile idiopathic arthritis (JIA) is a heterogeneous group of disorders, including all forms of arthritis, which develops in children who are less than 16 years old. Juvenile idiopathic arthritis (JIA) is an inflammatory disorder characterised by chronic arthritis and comprising all forms of arthritis that develop in children younger than 16 years of age. It lasts more than 6 weeks, with an unknown cause. Less is known about the relationship between the genetic and Juvenile idiopathic arthritis has been classified by the International League of Associations for Rheumatology (ILAR) into the following seven subtypes: systemic, oligoarticular, rheumatoid factor (RF) positive and RF negative polyarticular, enthesitis-related arthritis (ERA), psoriatic, and ‘other’ JIA [3]. Few reports from the Middle East and North Africa (MENA) described JIA among Arab children [4,5,6,7,8,9,10]

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