Juvenile granulosa cell tumour of testis in a 9-week-old infant: a case report

Abstract

Background Juvenile granulosa cell tumour (JGCT) is a rare benign neoplasm of testicular stroma that accounts for 1–5% of tumours arising in prepubertal testis. JGCT is uncommon in older children and adults. Occasional JGCT have occurred in undes-cended testis of infants with intersex disorders. Case report We present a case of 9-week-old infant with a mass in the right testis for which right orchidectomy was performed. Macroscopically, there was a 1 cm cystic lesion confined to the testis. Microscopically, the lesion was multicystic with a follicu-lar pattern. Follicles were lined by single to multiple layers of large cells with oval nuclei, inconspicuous nucleoli and abundant pale eosinophilic to clear cytoplasm. Follicles contained baso-philic secretions which were PAS and mucicarmine positive. There were frequent mitoses. The tumour showed positive staining for inhibin and S100. There was no staining for AFP and PLAP. Discussion JGCT usually presents in the first 6 months of life. Common differential diagnosis is yolk sac tumour, particularly when the tumour has a reticular pattern with brisk mitotic activity. AFP and alpha-inhibin immunostains are helpful in distinguishing these entities. JGCT follows a benign clinical course with no reports of metastasis. Some case series have advocated partial orchiectomy in management of these tumours.