Abstract
Objective. The article presents the juvenile depression treatment effectiveness with antidepressants of the selective serotonin reuptake inhibitors group (SSRIs).
 Materials and methods.182 patients were examined, including 114 men (62.6%) and 68 women (37.4%), age range 16 to 25 years, on treatment in a psycho-neurological dispensary in the city of Korolev (Russia, Moscow region) from 2014 to 2018.
 Results and Discussion.Main characteristics comparison of SSRIs antidepressants therapeutic effect in young men and adults of mature age revealed statistically significant age differences concerning the onset rate and these drugs antidepressant effect characteristics, as well as the adverse events nature.
 Conclusion. The SSRIs antidepressants clinical action regularities for depression treatment in adolescence, their therapeutic effect features and dynamics allow us to state adequate indications for the these drugs administration in adolescence, considering their age specificity.
 Bangladesh Journal of Medical Science Vol.18(3) 2019 p.615-623
Highlights
The problem of determining the occurrence conditions and clinical manifestations patterns for depressions that manifest in adolescence is among the most pressing and complex clinical psychiatry tasks
Drug response has specific age characteristics for patients with adolescent depressions to psychopharmacological Selective serotonin reuptake inhibitors (SSRIs) drugs, revealing a clear relationship between adolescent depression therapeutic effect and typological types, their nosological affiliation and depressive affect component that dominates in their picture
Paroxetine and citalopram have a balanced clinical effect: when in use, thymoleptic effect itself is primarily manifested, and fluoxetine is an antidepressant with a pronounced stimulating effect
Summary
The problem of determining the occurrence conditions and clinical manifestations patterns for depressions that manifest in adolescence is among the most pressing and complex clinical psychiatry tasks. Q) In order to determine the clinical action agerelated features and SSRIs antidepressants side effects in adolescent patients, a comparison was made of similar indicators of the depression treatment in patients of mature age, conducted according to the same standardized regimens For this purpose, the results of studies were used, that were conducted in the time range 2014-2018 in the neuropsychiatric dispensary in the city of Korolev (Russia, Moscow region). SSRIs antidepressant effect (thymoleptic, stimulant and anxiolytic) characteristics study results in adolescent depressions showed, that the drugs studied differ in the average Hamilton Rating Scale reduction degree on day 42 (Table 1).
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