Justification of the composition of the base of the emulsion ointment for the fungal diseases skin treatment

Abstract

The relevance and socio-economic significance of the problem is determined by the prevalence of fungal diseases, which are affected by every fifth inhabitant of the planet (according to the World Health Organization). Among fungal diseases, dermatomycoses, which are complicated by infection and keratization of the skin, are of particular importance.
 In the treatment of dermatomycoses, a significant place belongs to external therapy (soft and liquid medicinal products). Dermatological medicinal products in Ukraine are mainly represented by drugs of foreign production – 58.2%.The range of multicomponent drugs affecting all links of the pathological process is 21%. Therefore, the development of a scientifically based composition and technology of a multicomponent soft medicine for the treatment of dermatomycoses is an urgent problem of our time.
 The goal of our research was to develop the optimal composition of the emulsion ointment base for the treatment of fungal skin diseases.
 The objects of the study were combinations in different ratios of surface-active substances, hydrophilic non-aqueous substances and emulsifiers. The osmotic properties of the experimental bases were studied using dialysis through a semipermeable membrane. The study of the rheological properties of the samples was carried out on a rotary viscometer Reotest-2 (USA) with a water circulation heater. Determination of colloidal stability (for emulsion systems) was carried out according to DSTU 4765:2007 «Cosmetic creams. General technical conditions». Determination of thermal stability was carried out according to DSTU 4765:2007 «Cosmetic creams. General technical conditions».
 Based on the conducted experimental studies, the composition of the base of the emulsion ointment was substantiated. Rheological studies have established the optimal concentration of surface-active substances in emulsions. The study of the osmotic activity of model emulsions made it possible to establish the optimal ratio of hydrophilic-non-aqueous solvents in the composition of model samples.
 On the basis of the conducted structural-mechanical and pharmacological studies, the composition of the emulsion base of the o/w type emulsion ointment was substantiated for treatment of fungal skin lesions: petroleum jelly (20.0 g), emulsifier No. 1 (5.0 g), PEO-400 (5.0 g), glycerin (5.0 g), Na-KMC (1.0 g), purified water up to 100.0 g.