JUSTIFICATION OF NITROXOLINE APPLICATION IN CONDITIONS OF GROWTH OF RESISTANCE OF UROPATHOGENES TO NEW GENERATIONS OF ANTIMICROBATES

Abstract

Nitroxoline is a synthetic uroantiseptic, effective against a wide range of gram-positive, gram-negative bacteria and fungi. For a long time it has been used for the treatment and prevention of acute, chronic and recurrent urinary tract infections, because to this day retains high activity against bacteria of the family Enterobacteriaceae. With increasing resistance of uropathogens to new antimicrobial drugs, Nitroxoline may be an alternative drug for the treatment of acute uncomplicated urinary tract infections. The results of scientific research on the importance of Nitroxoline as a first-line drug in the treatment of this nosological group of diseases are contradictory. This motivates the study and analysis of the professional literature in the direction of clinical efficacy and determining the place of Nitroxoline among other uroseptics in the treatment of urinary tract infections in today's conditions.