Abstract
Jumonji domain-containing protein 1A (JMJD1A) plays a key role in the development and progression of several cancers. Here, we showed that the expression of JMJD1A is increased in cervical cancer cells and tissues, and that suppression of JMJD1A inhibits proliferation, migration, and invasion of cervical cancer cells. JMJD1A induced transcription of c-Myc, which is essential for cervical cancer growth and progression. Clinical data showed that JMJD1A expression correlated with lymph node metastasis (P=0.031) and FIGO stage (P=0.007). Increased c-Myc levels were associated with tumor differentiation (P=0.007) and FIGO stage (P<0.001). JMJD1A protein levels correlated with c-Myc expression (P<0.001), and high co-expression of the two proteins correlated with a poor prognosis. Survival analysis showed that JMJD1A and c-Myc levels are independent prognostic factors for cervical cancer patients. These results suggest that JMJD1A is a promising therapeutic target in cervical cancer.
Highlights
Cervical cancer continues to be a leading cause of death among women in less developed countries including China [1, 2]
JMJD1A mRNA and protein levels in the cervical cancer HeLa, SiHa, ME-180, and C-33A cells were higher than in the non-tumorigenic human epithelial cell line HaCaT (P
Our study reveals the important role played by JMJD1A in cervical cancer
Summary
Cervical cancer continues to be a leading cause of death among women in less developed countries including China [1, 2]. Many recent studies have focused on cervical cancer, leading to reduced mortality rates; the underlying molecular mechanisms remain unclear [3,4,5,6]. Recent studies have indicated that increased JMJD1A expression is associated with the development of different types of cancer, including renal cell carcinoma [16], prostate cancer [17], and liver cancer [18]. The expression patterns and the potential prognostic role of JMJD1A in the pathogenesis of cervical cancer remain unclear. We investigated the expression and function of JMJD1A in cervical cancer cells and assessed its prognostic significance in cervical cancer
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