Abstract
Ovbiagele and Saver evaluated the effect of smoking on outcome following intravenous thrombolysis for acute ischemic stroke and found that recent smokers who received thrombolysis experienced better early outcomes compared to nonsmokers. see page 293 Commentary by Steven R. Levine, MD Cigarette use has been linked to progression of existing atherosclerosis, increased fibrinogen, C-reactive protein, and homocysteine1 as well as vascular endothelial dysfunction. Smoking’s effects on clotting dynamics are more complex, and may depend on patient age and presence of atherosclerosis. Tissue plasminogen activator (t-PA) antigen and activity levels, plasminogen …
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