Jugular vein temperature reflects brain temperature during hypothermia

Abstract

Purpose: The neuroprotective properties of mild to moderate hypothermia are well recognized but may not be employed correctly because brain temperature cannot usually be measured directly. This study investigated the jugular vein as a more accessible site that accurately reflects the actual brain temperature during mild, induced hypothermia. Methods: We selected ten mongrel dogs (mean weight 12±2 kg) and measured temperatures of the brain, jugular vein, cisterna magna, pulmonary artery and rectum during hypothermia, including cooling and rewarming. The brain temperature needle probe was inserted 2.0 cm into the parenchyma. A temperature probe was placed in the cisterna magna with an epidural needle. Swan–Ganz thermistor probes measured the jugular venous and pulmonary artery blood temperatures. Result: The brain temperature decreased from 37.5±0.3 to 33.0±0.3°C over an average 150±45 min cooling period. Stable cool was maintained for 245±32 min, followed by 165±50 min for rewarming from 33.5±0.3 to 37.5±0.3°C. Jugular, cisterna magna and pulmonary arterial blood (PAB), but not rectal temperature, were close to brain temperature during stable cool. The mean jugular and cisterna magna temperatures were near the brain temperature at 0.1°C higher and 0.1°C lower, respectively. No significant effects of hypothermia were noted on hemodynamics in any phase. Conclusion: Jugular vein temperature, along with cisterna magna and pulmonary artery blood and rectal temperature, reflected brain temperature during hypothermia. The jugular vein and cisterna magna sites more sensitively reflected brain temperature than other sites.