Abstract
Antibiotics are the most widely injudiciously used drugs for therapeutic purposes throughout the world. This study aimed to detect cephalexin residue after discriminate and indiscriminate administration of cephalexin antibiotic in broiler. Eighteen broiler chicks, DOC (Cobb-500) were collected & reared for up to 31 days. The chicks were randomly divided into three groups namely control group (Group-A), discriminate cephalexin group (Group-B) and indiscriminate cephalexin group (Group-C). Each group consists of 6 birds. In this investigation, only a detectable level of antibiotic residues was found in indiscriminate group of poultry. A total of 72 samples were investigated by the TLC method. The overall residue of cephalexin found in indiscriminate group as in liver (100%), kidney (83.33%), thigh muscle (25.00%), breast muscle (8.33%), fat and spleen (66.67%) respectively. The final average body weight were recorded highest in indiscriminate antibiotic group (1804.17 ± 73.92gm) followed by discriminate group (1741.33 ± 63.63gm) and control group (1453.33 ± 26.39gm). The body weight was found significantly (p<0.05) higher in the antibiotic treated groups. The hematological parameters such as Hb, PCV and TEC values of treatment groups showed significantly (p<0.05) lower, while PCV did not show any significant difference compared to the control group. Overall, the present study documented the widespread abuse of cephalexin and failure to implement the recommended withdrawal period will undeniably lead to deposition of residues in broiler tissues.
Highlights
Antibiotics are used widely in the poultry industry as therapeutic, prophylactic and growth promoters [1]
There was established a marked change in the hemoglobin level and in the number of total erythrocyte count towards reduction (Table-2) in the case of cephalexin antibiotic (P< 0.01) in discriminate antibiotic group (Group-B) & indiscriminate antibiotic group compared with the control group whereas the packed cell volume did not show any significant changes [12, 13, 15, 18]
In discriminate group (Table-3) of broiler, antibiotic residues were found in liver 100%, kidney 83.33% and in fat 66.67% whereas residue was absent in breast muscle
Summary
Antibiotics are used widely in the poultry industry as therapeutic, prophylactic and growth promoters [1]. Antibiotics are used in required for efficient production of poultry products such as eggs and meat. Antibiotics improve growth rate, increase feed utilization, reduce mortality and morbidity. Antibiotics help to prevent and treat diseases [2]. Antibiotics are directly used in poultry production for different purposes [3]. Indiscriminate use of antibiotics causes deposition of antibiotic residues in the edible tissues of poultry [4]. Antibiotic residues result in antibiotic resistance, toxicity, teratogenicity, carcinogenicity and different public health problem associated with hypersensitivity reaction [5]
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