Abstract
Investigating potential biological relationships between heart failure (HF) with preserved ejection fraction (HFpEF) and associated diseases has been the focus of much research to establish personalized therapies. Hypertension is the most common concomitant disease in HFpEF patients, but the functional links between HFpEF and hypertension are still not fully understood and effective therapeutic strategies are still lacking. The structure of the left atrium (LA) is important for the diagnosis of HFpEF. In the SPRINT sub-analysis, intensive blood pressure control was not associated with ECG-defined LA abnormalities. In the ARGO-SIIA project, LA volumes indexed by height2 were more sensitive to subclinical hypertensive organ damage than those indexed by body surface area (BSA) in females. In the ARIC study, minimal LA volume index, but not standard assessment by maximum LA volume index, was associated with increased risk of incident HF or death regardless of measures of left ventricular function and NT-proBNP. In this presentation, the latest findings regarding the structure of the LA are updated and summarized in relation to HFpEF.
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