Abstract
Genome analyses using next-generation sequencing are providing more and more information on DNA sequences. However, there is a trend towards the return to RNA sequencing analyses, including both mRNAs and RNAs as simultaneous regulatory molecules. Consequently, enhancer RNA (eRNA) molecules are now extensively studied. The existence of eRNAs has been known for some time, but their roles are not yet fully understood. It turns out that the sequences of super-enhancers (hyperactive enhancers) have a significant and stimulating effect on the expression of oncogenes. Enhancers act at the level of transcription initiation and interact with many transcription factors that bind to DNA. Therapies targeting molecules that regulate gene expression may be effective cancer treatments, independent of tumor type, but relying on transcription factors and super-enhancers universally overexpressed in various types of cancer. This kind of treatment could become a new tissue-agnostic anticancer therapy.
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