Abstract
Joro spider toxin (JSTX), as the name implies, was isolated from the venom of the Joro spider (Nephila clavata) in the 1980s; a synthetic preparation is now available. JSTX is a potent, non-competitive, irreversible, or slowly reversible, antagonist of glutamate receptors. There is, however, debate concerning its specificity at the various ionotropic glutamate receptors, in that JSTX has been shown to inhibit NMDA receptors …
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