Abstract
Central blood pressure level is not always consistent with peripheral blood pressure level, and especially their joint effect on incident hypertension is not well established. A total of 1607 non-hypertensive subjects from an atherosclerosis cohort in Beijing, China were included. Central systolic blood pressure (cSBP) was obtained using Omron HEM-9000AI machine and peripheral systolic blood pressure (pSBP) was measured using Omron HEM-7117 electronic sphygmomanometer, separately. Hypertension was defined as BP ≥ 140/90 mmHg or self-reported hypertension or taking any antihypertension drugs at the follow-up survey. After a median follow-up of 2.3 years, incident hypertension was 13.1%. Every 1 standard deviation increase of cSBP and pSBP was associated with 1.98 (95%CI: 1.69–2.33) and 2.84 (95%CI: 2.30–3.52) times of incident hypertension after adjustment for confounders. Moreover, hypertension risk in single pSBP ≥ 120 mmHg group, single cSBP ≥ 120 mmHg group, and both pSBP and cSBP ≥ 120 mmHg group was 2.83 (95%CI: 0.98–8.16), 3.28 (95%CI: 1.24–8.70), and 11.47 (95%CI: 4.97–26.46) times higher than both pSBP and cSBP < 120 mmHg group, respectively. The joint effect of cSBP and pSBP is superior to either cSBP or pSBP to predict incident hypertension in a Chinese community-based population. Screening of central blood pressure should be considered in non-hypertensive population for the purpose of primary intervention, especially for subjects with pSBP ≥ 120 mmHg.
Highlights
Of central blood pressure with future hypertension risk
To better understand the different role of central and peripheral blood pressure in the prediction of hypertension, we designed this prospective study to investigate the impacts of central systolic blood pressure and peripheral systolic blood pressure on incident hypertension separately and jointly in a Chinese community-based population without hypertension at baseline
Among the 1,607 subjects enrolled at baseline, 211 (13.1%) subjects were found to be hypertensive after 2.3-year follow-up at 2014
Summary
Of central blood pressure with future hypertension risk. Recent studies suggest that central blood pressure may be a powerful predictor for future hypertension independent of conventional risk factors[12,13], but more compelling evidence is still needed. There are no previous trials investigating the joint effect of central blood pressure and peripheral blood pressure on hypertension risk, so whether central blood pressure can provide incremental value over peripheral blood pressure in risk profile for hypertension prevention remains to be elucidated. To better understand the different role of central and peripheral blood pressure in the prediction of hypertension, we designed this prospective study to investigate the impacts of central systolic blood pressure (cSBP) and peripheral systolic blood pressure (pSBP) on incident hypertension separately and jointly in a Chinese community-based population without hypertension at baseline
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