Joint Destruction in Arthritis and Osteoarthritis

Abstract

Cartilage destruction in arthritis and osteoarthritis.- Osteoarthritis in the human knee: A dynamic process of cartilage matrix degradation, synthesis and reorganization.- Experimental arthritis models in the study of the mechanisms of articular cartilage loss in rheumatoid arthritis.- Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model.- Mechanisms of cartilage destruction in joint inflammation.- Immunopathology.- Synovial fluid analyses detect and differentiate proteoglycan metabolism in canine experimental models of osteoarthritis and disuse atrophy.- Humoral and cell-mediated sensitivity to cartilage constituents in mice with antigen-induced arthritis.- In vitro and in vivo effects of proteoglycan fractions in adjuvant treated rats.- Are antibodies reactive with chondrocyte proteins enriched in synovial fluids of patients with rheumatoid arthritis?.- Joint loading and cartilage metabolism.- The metabolic response of articular cartilage to abnormal mechanical loading induced by medial or lateral meniscectomy.- Effects of long-term running exercise on canine femoral head articular cartilage.- Human and bovine articular cartilage loading measured with a new resistive sensor: Effects of protease degradation and osteoarthritis.- Cytokines and growth factors.- Possible role of IL-1 in arthritis: Effects of prostaglandins in the regulation of IL-1 synthesis and actions.- Degradative and repair responses of cartilage to cytokines and growth factors occur via distinct pathways.- Does TGF-ss protect articular cartilage in vivo?.- Human rheumatoid synovial cells (HRSC) in culture express TGF-ss receptors and are growth stimulated by the factor.- Variable TGF-ss receptor expression regulates TGF-ss responses of articular chondrocytes.- Proteases and their inhibitors.- Proteolytic degradation in human articular cartilage: Its relationship to Stromelysin.- The inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by cysteine endopeptidase inactivators.- The role of alpha-l-protease inhibitor (A1PI) in the inhibition of protease activity in human knee osteoarthritis.- Recombinant human protease nexin-1 prevents articular cartilage- degradation in the rabbit.- Therapeutic modulation of destruction.- In vitro effects of NSAIDs and corticosteroids on the synthesis and secretion of interleukin 1 by human osteoarthritic synovial membranes.- Animal models of early osteoarthritis: Their use for the evaluation of potential chondroprotective agents.- The in vivo effects of Naproxen on canine experimental osteoarthritic articular cartilage: Composition, metalloproteinase activities and metabolism.- Interleukin-1 and Naproxen down-regulate the expression of IL-1 receptors in cultured human rheumatoid synovial cells (HRSC).- Effect of Rumalon (glycosaminoglycan-peptide) on the articular tissue.- Doxycycline protects serum alpha-l-antitrypsin from human neutrophil collagenase.- In vitro construction of cells-containing implants for articular cartilage regeneration.- Cellular aspects on treatment of cartilage injuries.- Human meniscus transplantation.- Methodology.- In situ hybridisation for Decorin mRNA in rabbit synovium during antigen-induced arthritis.- Osteoarthritis in rhesus macaques: Assessment of cartilage matrix quality by quantitative magnetic resonance imaging.- A magnetic resonance imaging study of joint degeneration in the guinea pig knee.- Development of immortalized human articular cartilage cell lines.