Joint analysis of longitudinal measurements and spatially clustered competing risks HIV/AIDS data.

Abstract

The joint modeling of repeated measurements and time-to-event provides a general framework to describe better the link between the progression of disease through longitudinal measurements and time-to-event outcome. In the survival data, a sample of individuals is frequently grouped into clusters. In some applications, these clusters could be arranged spatially, for example, based on geographical regions. There are two benefits of considering spatial variation in these data, enhancing the efficiency and accuracy of the parameters estimations, and investigating the survivorship spatial pattern. On the other hand, in survival data, there is a situation that subjects are supposed to experience more than one type of event potentially, but the occurrence of one type of event prevents the occurrence of the others. In this article, we considered a Bayesian joint model of longitudinal and competing risks outcomes for spatially clustered HIV/AIDS data. The data were from a registry-based study carried in Hamadan Province, Iran, from December 1997 to June 2020. In this joint model, a linear mixed effects model was used for the longitudinal submodel and a cause-specific hazard model with spatial and spatial-risk random effects was used for the survival submodel. Also, a latent structure was defined by random effects to link both event times and longitudinal processes. We used a univariate intrinsic conditional autoregressive (ICAR) distribution and a multivariate ICAR distribution for modeling the areal spatial and spatial-risk random effects, respectively. The performance of our proposed model using simulation studies and analysis of HIV/AIDS data were assessed.