Abstract
s1 April 1963John Phillips Memorial Lecture: Observations on Metabolism of Aldosterone in Man.John A. Luetscher, M.D.John A. Luetscher, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-58-4-719_3 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe circulating level of aldosterone reflects the balance between rate of secretion by the adrenals and metabolic clearance rate by the liver. Although the concentration of aldosterone in plasma is too low to be measured accurately, the mean plasma level can be calculated. Secretion rate is estimated from measured specific activity of a purified metabolite after injection of labeled aldosterone. In most instances, the quantity released from strongly acidified urine serves as a fair index of secretion rate; but in pregnancy, renal insufficiency, or hepatic cirrhosis, the fraction of secreted aldosterone metabolized to this form is abnormal. Metabolic clearance rate... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: John A. Luetscher, M.D.Affiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 April 1963Volume 58, Issue 4Page: 719-719KeywordsAldosteroneAttentionBlood plasmaCirrhosisLiverMetabolitesPregnancyUrine ePublished: 1 December 2008 Issue Published: 1 April 1963 PDF downloadLoading ...
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