Abstract
Background and Aims : Atherosclerosis is a chronic inflammatory disease, which drives the progression of luminal plaques in arteries. T cells help orchestrate the underlying inflammation through polarization into pro-atherogenic and atheroprotective subsets. Epigenetic signatures including H3K27me3 can skew T-cell polarization, which may ultimately affect atheroprogression. We hypothesize the H3K27 demethylase, Jumonji domain containing 3 (JMJD3) may contribute to atheroprogression through modulation of T helper (Th) cell polarization.
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