Jet-Induced Tissue Disruption for Blood Release.

Jiali Xu,Andrew J Taberner,Bryan P Ruddy,James W Mckeage,Poul M F Nielsen

doi:10.1109/tbme.2021.3129606

Jiali Xu, Andrew J Taberner + Show 3 more

Open Access

https://doi.org/10.1109/tbme.2021.3129606

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Abstract

Needle-free jet injection is a drug delivery technique that uses the momentum of the fluid drug to break through the skin. This technique has recently also been applied to blood release, aiming to collect samples from capillaries in the skin without needing a lancet prick. This work provides new information about the wound geometry and tissue disruption caused by shallow jet injection with circular-shaped and slot-shaped jets. We use histological analysis to compare the disruption of tissue, including blood vessels, caused by lancet-pricking and jet injection with a circular-shaped jet and a lancet-inspired slot-shaped jet. Intradermal injection into porcine skin using a slot-shaped jet disrupted more vascular endothelium in the tissue than a circular-shaped jet and did so at a smaller penetration depth with smaller wound volume. Our results suggest that shallow jet injections may have the potential to release more capillary blood than a lancet prick. These findings demonstrate that a reversible jet injector might be used in diabetes management as a device to release and collect blood samples, in addition to being used to deliver insulin. Tissue disruption is crucial to consider when using jet injection to deliver drugs and release capillary blood.

Highlights

DIABETES is among the top 10 causes of death
This study examined the disruption of porcine tissue resulting from three interventions: a lancet prick, and jet injection with a slot-shaped nozzle and circular-shaped nozzle
We have demonstrated that a needle-free jet injector can be used to disrupt small blood vessels in the skin

Summary

Introduction

DIABETES is among the top 10 causes of death. It can lead to disabling and life-threatening health complications such as cardiovascular disease, nerve damage, kidney damage, and eye disease [1]. Diabetics typically monitor and regulate their blood glucose levels by pricking their fingers multiple times a day with a lancet. The use of lancets is associated with issues such as sharps waste, accidental needle-stick injury, and needle phobia [2]. To address these issues, and potentially improve patient compliance, we propose to use the high-speed fluid of a jet injector to penetrate skin and disrupt blood vessels. Potentially improve patient compliance, we propose to use the high-speed fluid of a jet injector to penetrate skin and disrupt blood vessels This technique could provide an alternative to a lancet in capillary blood sampling

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