Abstract
There was no substantial decline in mumps neutralizing antibody up to two years following Jeryl Lynn strain vaccine compared with the titer one month after vaccination. The pattern of antibody persistence closely approximated that observed following natural mumps. Initially seronegative children who received the vaccine 8 to 20 months previously were followed up for immunity to natural mumps challenge during a second mumps season. Fifty-three cases of mumps occurred among 78 initially susceptible controls in contrast to two cases among 53 initially susceptible vaccinees, giving a protective efficacy of 94%. The two vaccine failures were in children who did not respond serologically to the vaccine. The pattern of antibody persistence suggests that immunity following vaccination will be lasting.
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