Jerry A Nathanson Basic Environmental Technology — Water Supply, Waste Management and Pollution Control 4 th ed 2002 Published by Prentice Hall of India Pvt Ltd. New Delhi 81-203-2228-2 Pages 532 Price Rs 325 (Indian Reprint)

Abstract

Polychlorinated naphthalenes (PCNs) are produced from a variety of industrial sources, and they reach the aquatic ecosystems by the dry-wet deposition from the atmosphere and also by the drainage from the land surfaces. Then the PCNs can be transmitted through the food chain to humans and show toxic effects on different aquatic animals as well as humans. Considering this scenario, it is an obligatory task to explore the toxicity data of PCNs more deeply for the species of an aquatic ecosystem (green algae-Daphnia magna-fish), and to extrapolate those data for humans. But the toxicity data for different aquatic species are quite limited. The laboratory experimentations are complicated and ethically troublesome to fill toxicity data gaps; therefore, different in silico methods (e.g., QSAR, quantitative read-across predictions) are emerging as crucial ways to fill the data gaps and hazard assessments. In the present study, we developed individual toxicity models as well as interspecies models from the 75 PCN toxicity data against three aquatic species (green algae-Daphnia magna-fish) by employing easily interpretable 2D descriptors; these models were validated rigorously employing different globally accepted internal and external validation metrics. Then we interpreted the modelled descriptors mechanistically with the endpoint values for better understanding. And finally, we endeavored to improve the prediction quality in terms of external validation metrics by employing a novel quantitative read-across approach by pooling the descriptors from the developed individual QSAR models.