Jejunal Gastrointestinal Stromal Tumour Presenting with Profound Lower Gastrointestinal Bleeding

Abstract

Gastrointestinal stromal tumours (GISTs) are uncommon malignant mesenchymal neoplasms that affect the gastrointestinal (GI) system. We describe the case of a 45-year-old man who arrived at the emergency room with haemodynamic instability and profound lower GI haemorrhage. Despite early resuscitation efforts, bleeding continued, necessitating a further investigation. A sizable solid-cystic lesion in the jejunum that was heterogeneously enhancing was seen on computed tomography abdominal angiography. Urgent surgical exploration was performed, uncovering a large mid-jejunal tumour that was successfully removed, restoring haemodynamic stability. A histopathological analysis verified the presence of GIST, an uncommon jejunal occurrence. This case study emphasises the necessity of investigating GIST as a differential diagnosis in individuals presenting with significant lower GI bleeding, even if it is uncommon for their age. Surgical excision remains the cornerstone of care for localised, non-metastatic GISTs, especially in situations of severe bleeding when radiologic therapies are not possible due to haemodynamic instability.