Abstract
ABSTRACTOsteosarcoma of the jaw represents less than 1% of all head and neck malignancies. This malignancy in pregnant women occurs in one per 1000 deliveries. We report a case of a 29-year-old woman, in the 33rd week of gestation, who presented with an expansive tumor destroying the maxillary alveolar bone, histologically composed of pleomorphic, round, spindle, or epithelioid cells and osteoid/chondroid matrix. Upon final diagnosis of osteosarcoma, the lesion was excised. To the best of our knowledge, only 10 cases of jaw osteosarcoma in pregnant women have been reported to date in the English language literature. The use of ancillary examinations, malignancy diagnosis, and cancer treatment can be challenging during pregnancy. Knowledge about jaw osteosarcoma in pregnancy can increase healthcare providers’ awareness, avoid delays and misdiagnosis and potentially improve maternal and neonatal outcomes.
Highlights
Osteosarcoma is a malignant and aggressive bone tumor characterized by osteoid tissue or immature bone by tumor cells.[1]
We present a rare case of conventional osteosarcoma in the maxilla of a pregnant woman and a literature review
Primary osteosarcoma in the jaws during pregnancy is a rare event
Summary
Osteosarcoma is a malignant and aggressive bone tumor characterized by osteoid tissue or immature bone by tumor cells.[1]. It frequently affects long bones in the appendicular skeleton, such as the femur. Cancer diagnosis in a pregnant patient may be challenging since there are overlapping symptoms common in pregnancy and malignant disease; there are insecurities in the safety of several ancillary examinations in this population. Immunohistochemical reactions were performed for AE1/AE (AE1/AE3, dilution 1:50, Dako), epithelial membrane antigen (E29, dilution 1:50, Dako), HMB45 (HMB45, dilution 1:50, Dako), and vimentin (V9, dilution 1:400, Dako) antibodies, and the lesion cells were positive only for vimentin It was suggestive of osteosarcoma, the biopsy was superficial, with an extensive ulcerated area covered by necrosis, in addition to an intense inflammatory infiltrate.
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