Abstract
The local deformation of a bilayer due to protein-bilayer hydrophobic mismatch has an associated energetic cost, the bilayer deformation energy (ΔGdef), which contributes to the total energetic cost of membrane protein conformational changes (ΔGtotal). We present an analytical solution to the continuum elastic model of protein-induced bilayer deformations (Nielsen et al., 1998, 2000), which allows us to calculate ΔGdef for a cylindrical membrane inclusion, together with a user-friendly Java implementation that calculates ΔGdef for two different states (different hydrophobic lengths) of an inclusion.
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