Abstract
Simple SummaryJasonia glutinosa (L.) DC or rock tea (RT) is a plant traditionally used to treat different pathologies. In this study the neuroprotective potential of an ethanolic extract of RT is analyzed. Caenorhabditis elegans model and in vitro assays with relevant central nervous system enzymes were used. The results showed antioxidant and neuroprotective potential of this plant.In traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in Caenorhabditis elegans (C. elegans) as an in vivo model, and through in vitro assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of C. elegans CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase in vitro. Together these results demonstrate that Jasonia glutinosa is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests.
Highlights
The objective of this work is to study the antioxidant neuroprotective activity of rock tea (RT) extract in a Caenorhabditis elegans (C. elegans) model, studying and neuroprotective activity of RT extract in a Caenorhabditis elegans (C. elegans) model, the effect of J. glutinosa on stress resistance, lifespan and amyloid toxicity and in vitro anastudying the effect of J. glutinosa on stress resistance, lifespan and amyloid toxicity and in lyzing its ability to inhibit the enzymes of the nervous system such as acetylcholinesterase vitro analyzing its ability to inhibit the enzymes of the nervous system such as acetylcho(AChE), monoamine oxidase A (MAO-A) and tyrosinase (TYR), involved in neurotransmitlinesterase (AChE), monoamine oxidase A (MAO-A) and tyrosinase (TYR), involved in ters’ metabolism
To evaluate the antioxidant effect of J. glutinosa, wild-type C. elegans were pre-treated with RT extract (5, 10, 20 and 50 μg/mL) for 24 h and exposed to a lethal dose of with RT extract (5, 10, 20 and 50 μg/mL) for 24 h and exposed to a lethal dose of juglone, a natural pro-oxidant
Jasonia glutinosa is a medicinal plant with a wide range of traditional uses
Summary
(Compositae), whose popular name is “té de roca” (rock tea, RT), is a medicinal plant distributed in Mediterranean countries, mainly Spain and France [1]. Ethnobotanical studies on this plant report that its main use, as an infusion, is for the treatment of diarrhea, dyspepsia or abdominal pain [2]. These digestive properties were demonstrated for the first time in a murine model of colitis [3,4]. The oral administration of an ethanolic extract of RT (5, 25 and 50 mg/kg) ameliorated colitis symptomatology, prevented the macroscopic damage and histological changes induced by dextran sulfate sodium in mice and normalized the intestinal contractibility and the intestinal total transit disrupted by the colitis [3,4]
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